VemoZyme® P is a stable, broad spectrum protease, optimized to work efficiently in the animal’s digestive system.

 

Enzyme Characteristics


VemoZyme® P is with activity of min 15 000 units per gramme.
Definition: The proteolytic activity (PA) is expressed in tyrosine units and is defined as the quantity of enzyme preparation, which liberates 1 μg tyrosine from casein for 1 minute at 30°С and рН 7.0.

 

VemoZyme® P: temperature range and stability


Еnzymes are complex biological systems that strongly rely on their structure which is temperature-dependent. They perform best at their optimum temperature but do not cope well with the high temperatures associated with the feed pelleting process.
VemoZyme® P is designed to be heat resistant and demonstrates high stability (up to 90°C) during the feed production process.
VemoZyme® P works best in temperatures of 37-60°C, thus it is most effective in the animal’s body (average body temperature for poultry – 42°C, for pigs – 38°C).

 

VemoZyme® P: pH stability in the animal’s digestive system

 

An alkaline protease such as VemoZyme® P works best at high pH – as it is in the small intestine. 80% of nutrient uptake takes place in the small intestine. As nutrient digestion starts in the mouth, a well-designed feed grade protease preparation should be able to remain active throughout the digestion process – from the mouth to the hindgut and to withstand the acidic pH of the stomach.VemoZyme® P was tested against the acidic pH conditions in the development stage and in animal trials. VemoZyme® P endures the acidic conditions in the animal’s digestive system and preserves its activity so the effectiveness of the product remains intact. 

VemoZyme® P protease has a broad pH range of 5.5 – 9.5 with an optimal of 6.0 – 7.5 and works best in the small intestine.

 

Application


VemoZyme® P is a broad-spectrum protease complex that:
♦ Improves protein digestibility and availability in animal feed;
♦ Allows the use of lower quality protein alternatives in the diet;
♦ Saves on feed costs.

As a result of the action of protease from VemoZyme® P, the pathogenic bacteria growth in the intestines is limited. That leads to improved gut health and ultimately, improved animal performance and enhanced growth.

Protein comes in a variety of forms, with regards to its digestibility – it can be easily degradable like the proteins found in soybean meal or hard to digest like keratin and elastin. With this in mind, VemoZyme® P is formulated to work on a wide array of protein types from both plant and animal origin (feather meal, soybean meal, meat products, etc).

 

Biological Action


Proteases are an enzyme class known by many names: proteolytic enzymes, peptidase, proteinase. This enzyme group is most abundant in animals. These enzymes target specific bonds present in the protein molecule. As a result of the proteinase activity the protein molecules are cut into smaller pieces known as polypeptides, and ultimately to their building blocks – the amino acids.

The best-known proteolytic enzymes are the digestive ones – trypsin, chymotrypsin and others. Studies show that non-ruminants are able to digest only 80 to 90% of the total protein available from feed. The other 10 – 20 % make their way to the colon, where the protein takes part in a process known as hindgut fermentation. Protein fermentation facilitates the development of pathogenic bacteria that cause inflammation and damage the small intestine lining. The infected animals rarely recover, and the ones that do, lose a lot of body mass. 

Feed traders observe an ascending trend in protein feed prices on the world feed market. This new trade microclimate has caused farmers to look towards the protease enzyme family as a way to decrease feed costs by making protein in feed more digestible, which reduces feed consumption and keeps the animals healthier.

Indigestible proteins can be degraded by proteases, generating peptides that are easily manageable by the animal. Implementing VemoZyme® P allows the use of low crude protein fodder with low quality amino acids, thus reducing feed cost without affecting animal productivity.

 

Piglets and Protein


Young piglets need high amounts of digestible protein in their diet to facilitate early growth and muscle mass accumulation. However, diets high in protein can cause intestinal disorders, scours and ultimately increase morbidity through excess protein fermentation in recently weaned piglets. The most common source of protein for animal diets is soybean meal (SBM). While this type of protein does not pose serious threat to older pigs, newly weaned piglets have difficulties digesting it. Soybean meal also contains trypsin inhibitors and the allergenic proteins glycinin and ß-conglycinin, which cause protein indigestibility, intestinal inflammation and lead to disruption of the gut barrier functions and loss of appetite.

Using VemoZyme® P for piglets:
♦   improves feed digestibility that results (amongst other things) in enhanced growth;
♦   leads to better feed efficiency regardless of the protein content;
♦   reduces protein fermentation that leads to improved intestinal functions and less pathogenic bacteria growth in the intestine.

High protein diets are usually accompanied by a high diarrhea rate, however when such diets are supplemented with protease enzyme the diarrhea rate goes down to levels equivalent to a low protein diet without protease. The main driving force behind enzyme development for the needs of livestock producers has been the idea of reducing feed costs, without loss in animal performance. Implementing VemoZyme® P in the feed of piglets improves animal nutrition and performance at the early stages of development, adding more hidden value to future livestock.

Adding protease to high protein diets, improves animal performance by 20% on average. These results can be credited to higher digestibility and also to less protein fermentation, which in turn leads to healthier gut and better nutrient uptake.

 

Dosage


250 g/t feed for layers, broilers and swine

 

Storage


Store in a cool and dry place, at a temperature under 25°C

 

Experimental Data

VemoZyme® P in broilers feed

VemoZyme® P in pigs feed

PC: Positive control
NC: Negative control with 5% reduced level of crude protein in the diet
NC+VemoZyme® P: NC + VemoZyme® P (250 g/t feed)

PC: Positive control fed with corn-soy blend feeds
NC: Negative control fed with reduced level of crude protein feeds
NC+VemoZyme® P: NC + VemoZyme® P (250 g/t feed)

Conclusion
The addition of VemoZyme® P to the compound feeds with a reduced level of crude protein results in an increase of the body weight of broilers and better feed conversion ratio (FCR). In addition, the combined price of lower crude protein feeds and VemoZyme® P is better than that of the positive control feed.

Conclusion
The addition of VemoZyme® P to compound feeds with reduced level of crude protein allows part of the soybean meal to be replaced with cheaper and lower quality feeds, without decreasing animal performance. In addition, the end price of the lower crude protein feeds and VemoZyme® P is better than that of the positive control feed.